The glucocorticoid receptor gene (NR3C1) is linked to and associated with polycystic ovarian syndrome in Italian families
Abstract Objectives Components of the hypothalamic-pituitary axis (HPA) pathway are potential mediators of the genetic VEGI SOUP MIX risk of polycystic ovarian syndrome (PCOS).Impaired glucocorticoid receptor (NR3C1) expression and function may underlie impaired HPA-axis cortisol activity, thereby also contributing to the increased adrenal cortisol